Highly polymorphic products of both HLA-DR and HLA-DQ genes contribute to the polymorphism of the HLA-DR w13 haplotype
Identifieur interne : 000314 ( France/Analysis ); précédent : 000313; suivant : 000315Highly polymorphic products of both HLA-DR and HLA-DQ genes contribute to the polymorphism of the HLA-DR w13 haplotype
Auteurs : J. Michon [France] ; Y. Henin [France] ; G. Sterkers [France] ; C. Freide [France] ; L. Gebuhrer [France] ; H. Betuel [France] ; J. Y. Muller [France] ; J. P. Levy [France]Source :
- Immunogenetics [ 0093-7711 ] ; 1986-09-01.
English descriptors
- Teeft :
- Antigen presentation, Antigenic specificity, Autologous, Cell line, Cell lines, Cellular typing, Clone, Common epitope, Culture medium, Determinant, Dwl9, Epitope, Functional epitopes, Haplotype, High degree, Immunol, Influenza, Influenza clones, Influenza virus, Institut pasteur, Ixlculture medium, Lymphocyte clones, Mabs, Michon, Microtiter plates, Monoclonal antibodies, Nomenclature report, Other haplotypes, Polymorphism, Positive results, Present antigen, Proliferation assays, Restriction analysis, Sterkers, Stimulator cells, Strong linkage disequilibrium, Tissue antigens, Triplicate cultures, Viral antigen, Virus strains.
Abstract
Abstract: We studied the polymorphisms of HLA-DR and HLA-DQ products from HLA-DRw13 haplotypes by analyzing the restriction of influenza A-specific cloned T cells from an HLA-DRw13,DQw1,Dw19 homozygous individual. The results show that (1) some functional epitopes, which can be borne by either HLA-DR or HLA-DQ molecules, are strictly correlated with the HLA-Dw19 subtype of HLA-DRw13. This clearly indicates that both HLA-DR and HLA-DQ products contribute to the HLA-Dw19 subdivision of HLA-DRw13. (2) At least two different restricting epitopes are borne by DR products: one is correlated with the HLA-DRwl3 serologically defined specificity, which includes Dw19 and Dw18 haplotypes; the other is correlated with the only HLA-Dw19 subtype of HLA-DRwl3. (3) Restricting epitopes borne by DQ molecules have been found on Dw19 cells only. (4) DQ-restricted clones were unable to react with DQwl APC of any other haplotypes tested, including DR1, DR2-long, DR2-short, and DRw14, demonstrating a high degree of functional polymorphism among the serologically defined DQw1 specificities.
Url:
DOI: 10.1007/BF00364746
Affiliations:
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Levy</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Immunologie et Virologie des Tumeurs, INSERM U152, CNRS UA 628, Hôpital Cochin 27, rue du Faubourg Saint-Jacques, 75674, Paris Cédex 14</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris Cédex 14</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Immunogenetics</title><title level="j" type="abbrev">Immunogenetics</title><idno type="ISSN">0093-7711</idno><idno type="eISSN">1432-1211</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1986-09-01">1986-09-01</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="177">177</biblScope><biblScope unit="page" to="183">183</biblScope></imprint><idno type="ISSN">0093-7711</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0093-7711</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antigen presentation</term><term>Antigenic specificity</term><term>Autologous</term><term>Cell line</term><term>Cell lines</term><term>Cellular typing</term><term>Clone</term><term>Common epitope</term><term>Culture medium</term><term>Determinant</term><term>Dwl9</term><term>Epitope</term><term>Functional epitopes</term><term>Haplotype</term><term>High degree</term><term>Immunol</term><term>Influenza</term><term>Influenza clones</term><term>Influenza virus</term><term>Institut pasteur</term><term>Ixlculture medium</term><term>Lymphocyte clones</term><term>Mabs</term><term>Michon</term><term>Microtiter plates</term><term>Monoclonal antibodies</term><term>Nomenclature report</term><term>Other haplotypes</term><term>Polymorphism</term><term>Positive results</term><term>Present antigen</term><term>Proliferation assays</term><term>Restriction analysis</term><term>Sterkers</term><term>Stimulator cells</term><term>Strong linkage disequilibrium</term><term>Tissue antigens</term><term>Triplicate cultures</term><term>Viral antigen</term><term>Virus strains</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: We studied the polymorphisms of HLA-DR and HLA-DQ products from HLA-DRw13 haplotypes by analyzing the restriction of influenza A-specific cloned T cells from an HLA-DRw13,DQw1,Dw19 homozygous individual. The results show that (1) some functional epitopes, which can be borne by either HLA-DR or HLA-DQ molecules, are strictly correlated with the HLA-Dw19 subtype of HLA-DRw13. This clearly indicates that both HLA-DR and HLA-DQ products contribute to the HLA-Dw19 subdivision of HLA-DRw13. (2) At least two different restricting epitopes are borne by DR products: one is correlated with the HLA-DRwl3 serologically defined specificity, which includes Dw19 and Dw18 haplotypes; the other is correlated with the only HLA-Dw19 subtype of HLA-DRwl3. (3) Restricting epitopes borne by DQ molecules have been found on Dw19 cells only. (4) DQ-restricted clones were unable to react with DQwl APC of any other haplotypes tested, including DR1, DR2-long, DR2-short, and DRw14, demonstrating a high degree of functional polymorphism among the serologically defined DQw1 specificities.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li><li>Île-de-France</li></region><settlement><li>Lyon Cédex 7</li><li>Paris</li><li>Paris Cédex 14</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Michon, J" sort="Michon, J" uniqKey="Michon J" first="J." last="Michon">J. Michon</name></region><name sortKey="Betuel, H" sort="Betuel, H" uniqKey="Betuel H" first="H." last="Betuel">H. Betuel</name><name sortKey="Freide, C" sort="Freide, C" uniqKey="Freide C" first="C." last="Freide">C. Freide</name><name sortKey="Gebuhrer, L" sort="Gebuhrer, L" uniqKey="Gebuhrer L" first="L." last="Gebuhrer">L. Gebuhrer</name><name sortKey="Henin, Y" sort="Henin, Y" uniqKey="Henin Y" first="Y." last="Henin">Y. Henin</name><name sortKey="Levy, J P" sort="Levy, J P" uniqKey="Levy J" first="J. P." last="Levy">J. P. Levy</name><name sortKey="Muller, J Y" sort="Muller, J Y" uniqKey="Muller J" first="J. Y." last="Muller">J. Y. Muller</name><name sortKey="Sterkers, G" sort="Sterkers, G" uniqKey="Sterkers G" first="G." last="Sterkers">G. Sterkers</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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